related proteins
> 50% identity

Zihlmann P, Silbermann M, Sharpe T, Jiang X, Mühlethaler T, Jakob R, Rabbani S, Sager C, Frei P, Pang L, Maier T, Ernst B.
KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany) 24 13049-13057 2018

Rabbani S, Fiege B, Eris D, Silbermann M, Jakob R, Navarra G, Maier T, Ernst B.
Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system. The Journal of biological chemistry 293 1835-1849 2018

Alvarez Dorta D, Chalopin T, Sivignon A, de Ruyck J, Dumych T, Bilyy R, Deniaud D, Barnich N, Bouckaert J, Gouin S.
Physiochemical Tuning of Potent Escherichia coli Anti-Adhesives by Microencapsulation and Methylene Homologation. ChemMedChem 12 986-998 2017

Sauer M, Jakob R, Eras J, Baday S, Eriş D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 7 10738 2016

de Ruyck J, Lensink M, Bouckaert J.
Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin. IUCrJ 3 163-7 2016

Jarvis C, Han Z, Kalas V, Klein R, Pinkner J, Ford B, Binkley J, Cusumano C, Cusumano Z, Mydock-McGrane L, Hultgren S, Janetka J.
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. ChemMedChem 11 367-73 2016

Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner J, Klein R, Kalas V, Crowley J, Rath N, Hultgren S, Janetka J.
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections. Journal of medicinal chemistry 59 9390-9408 2016

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 16 1235 2015

Vanwetswinkel, S., Volkov, A.N., Sterckx, Y.G.J., Garcia-Pino, A., Buts, L., Vranken, W.F., Bouckaert, J., Roy, R., Wyns, L., Van Nuland, N.A.J.
Study of the structural and dynamic effects in the FimH adhesin upon α-d-heptyl mannose binding. J. Med. Chem. 2014

Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.
Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. J. Med. Chem. 56 5395 2013

Roos, G., Wellens, A., Touaibia, M., Yamakawa, N., Geerlings, P., Roy, R., Wyns, L., Bouchaert, J.
Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH. ACS Med. Chem. Lett. 2013

Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J.
The tyrosine gate as a potential entropic lever in the receptor-binding site of the bacterial adhesin FimH. Biochemistry 51 4790 2012

Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J.
Wellens A, Lahmann M, Touaibia M, Vaucher J, Oscarson S, Roy R, Remaut H, Bouckaert J. Biochemistry 51 4790 2012

Wellens A, Garofalo C, Nguyen H, Van Gerven N, Slattegard R, Hernalsteens JP, Wyns L, Oscarson S, De Greve H, Hultgren S, Bouckaert J
Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex PLoS ONE 3 0 2008

Bouckaert J, Berglund J, Schembri M, De Genst E, Cools L, Wuhrer M, Hung CS, Pinkner J, Slattegard R, Zavialov A, Choudhury D, Langermann S, Hultgren
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin Mol. Microbiol. 55 441 2005
Jakob, R.P., Rabbani, S., Ernst, B., Maier, T.
Crystal structure of the FimH lectin domain from E.coli K12 in complex with methyl alpha-D-mannopyrannoside in spacegroup P21 To be published.
Zihlmann, P., Jiang, X., Sager, C.P., Fiege, B., Jakob, R.P., Siegrist, S., Zalewski, A., Rabbani, S., Eris, D., Silbermann, M., Pang, L., Muhlethaler, T., Sharpe, T., Maier, T., Ernst, B.
High-Affinity Carbohydrate-Lectin Interactions: How Nature Makes it Possible To be published.
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