P08191 protein in UniLectin3D

Reference of
8BVD structure
2023
PubMed

Mousavifar L, Sarshar M, Bridot C, Scribano D, Ambrosi C, Palamara A, Vergoten G, Roubinet B, Landemarre L, Bouckaert J, Roy R.
Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists. Pharmaceutics 2023

Reference of
8BXY structure
2023
PubMed

Krammer E, Bridot C, Serna S, Echeverria B, Semwal S, Roubinet B, van Noort K, Wilbers R, Bourenkov G, de Ruyck J, Landemarre L, Reichardt N, Bouckaert J.
Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors. The Journal of biological chemistry 2023

Reference of
8BY3 structure
2023
PubMed

Krammer E, Bridot C, Serna S, Echeverria B, Semwal S, Roubinet B, van Noort K, Wilbers R, Bourenkov G, de Ruyck J, Landemarre L, Reichardt N, Bouckaert J.
Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors. The Journal of biological chemistry 2023

Reference of
7AYN structure
2021
PubMed

Tomasic T, Rabbani S, Jakob R, Reisner A, Jakopin Z, Maier T, Ernst B, Anderluh M.
Does targeting Arg98 of FimH lead to high affinity antagonists? European journal of medicinal chemistry 2021

Reference of
5JCR structure
2018
PubMed

Zihlmann P, Silbermann M, Sharpe T, Jiang X, Mühlethaler T, Jakob R, Rabbani S, Sager C, Frei P, Pang L, Maier T, Ernst B.
KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany) 2018

Reference of
5MUC structure
2018
PubMed

Zihlmann P, Silbermann M, Sharpe T, Jiang X, Mühlethaler T, Jakob R, Rabbani S, Sager C, Frei P, Pang L, Maier T, Ernst B.
KinITC-One Method Supports both Thermodynamic and Kinetic SARs as Exemplified on FimH Antagonists. Chemistry (Weinheim an der Bergstrasse, Germany) 2018

Reference of
5MCA structure
2018
PubMed

Rabbani S, Fiege B, Eris D, Silbermann M, Jakob R, Navarra G, Maier T, Ernst B.
Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system. The Journal of biological chemistry 2018

Reference of
5FS5 structure
2017
PubMed

Rabbani S, Krammer E, Roos G, Zalewski A, Preston R, Eid S, Zihlmann P, Prévost M, Lensink M, Thompson A, Ernst B, Bouckaert J.
Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ 2017

Reference of
5FWR structure
2017
PubMed

Rabbani S, Krammer E, Roos G, Zalewski A, Preston R, Eid S, Zihlmann P, Prévost M, Lensink M, Thompson A, Ernst B, Bouckaert J.
Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ 2017

Reference of
5MTS structure
2017
PubMed

Alvarez Dorta D, Chalopin T, Sivignon A, de Ruyck J, Dumych T, Bilyy R, Deniaud D, Barnich N, Bouckaert J, Gouin S.
Physiochemical Tuning of Potent Escherichia coli Anti-Adhesives by Microencapsulation and Methylene Homologation. ChemMedChem 2017

Reference of
4XO8 structure
2016
PubMed

Sauer M, Jakob R, Eras J, Baday S, Eris D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 2016

Reference of
4XO9 structure
2016
PubMed

Sauer M, Jakob R, Eras J, Baday S, Eris D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 2016

Reference of
4XOB structure
2016
PubMed

Sauer M, Jakob R, Eras J, Baday S, Eris D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 2016

Reference of
4XOA structure
2016
PubMed

Sauer M, Jakob R, Eras J, Baday S, Eris D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 2016

Reference of
4XOD structure
2016
PubMed

Sauer M, Jakob R, Eras J, Baday S, Eris D, Navarra G, Bernèche S, Ernst B, Maier T, Glockshuber R.
Catch-bond mechanism of the bacterial adhesin FimH. Nature communications 2016

Reference of
5ABZ structure
2016
PubMed

de Ruyck J, Lensink M, Bouckaert J.
Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin. IUCrJ 2016

Reference of
5F2F structure
2016
PubMed

Jarvis C, Han Z, Kalas V, Klein R, Pinkner J, Ford B, Binkley J, Cusumano C, Cusumano Z, Mydock-McGrane L, Hultgren S, Janetka J.
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. ChemMedChem 2016

Reference of
5F3F structure
2016
PubMed

Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner J, Klein R, Kalas V, Crowley J, Rath N, Hultgren S, Janetka J.
Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections. Journal of medicinal chemistry 2016

Reference of
4CSS structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4CST structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4X5P structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4X5Q structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4X5R structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4X50 structure
2015
PubMed

Fiege, B., Rabbani, S., Preston, R.C., Jakob, R.P., Zihlmann, P., Schwardt, O., Jiang, X., Maier, T., Ernst, B.
The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography ChemBioChem 2015

Reference of
4LOV structure
2014
PubMed

Vanwetswinkel S, Volkov A, Sterckx Y, Garcia-Pino A, Buts L, Vranken W, Bouckaert J, Roy R, Wyns L, van Nuland N.
Study of the structural and dynamic effects in the FimH adhesin upon alpha-d-heptyl mannose binding. Journal of medicinal chemistry 2014

Reference of
3ZL1 structure
2013
PubMed

Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.
Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. J. Med. Chem. 2013

Reference of
3ZL2 structure
2013
PubMed

Brument, S., Sivignon, A., Dumych, T.I., Moreau, N., Roos, G., Guerardel, Y., Chalopin, T., Deniaud, D., Bilyy, R.O., Darfeuille-Michaud, A., Bouckaert, J., Gouin, S.G.
Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients. J. Med. Chem. 2013

Reference of
4ATT structure
2013
PubMed

Roos, G., Wellens, A., Touaibia, M., Yamakawa, N., Geerlings, P., Roy, R., Wyns, L., Bouchaert, J.
Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH. ACS Med. Chem. Lett. 2013

Reference of
4AUJ structure
2013
PubMed

Roos, G., Wellens, A., Touaibia, M., Yamakawa, N., Geerlings, P., Roy, R., Wyns, L., Bouchaert, J.
Validation of Reactivity Descriptors to Assess the Aromatic Stacking within the Tyrosine Gate of FimH. ACS Med. Chem. Lett. 2013

Reference of
4AUU structure
2012
PubMed