SMTL ID : 4kzv.1 (1 other biounit)

Structure of the carbohydrate-recognition domain of the C-type lectin mincle bound to trehalose

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.40 Å

Oligo State

monomer

Ligands

1 x GLC- GLC: alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose(Non-covalent)

GLC-GLC.1: 10 residues within 4Å: Chain A: E.58, E.91, N.93, L.95, E.99, R.105, N.115, D.116, F.121 Ligands: CA.2 7 PLIP interactions: 7 interactions with chain A Hydrogen bonds: A:E.91, A:N.93, A:E.99, A:R.105, A:R.105, A:N.115 Salt bridges: A:R.105

2 x CA: CALCIUM ION(Non-covalent)

CA.2: 6 residues within 4Å: Chain A: E.91, N.93, E.99, N.115, D.116 Ligands: GLC-GLC.1 4 PLIP interactions: 4 interactions with chain A Metal complexes: A:E.91, A:E.99, A:D.116, A:D.116 CA.3: 4 residues within 4Å: Chain A: V.39, N.41, E.45, E.128 5 PLIP interactions: 4 interactions with chain A, 1 Ligand-Water interactions Metal complexes: A:V.39, A:E.45, A:E.128, A:E.128, H2O.1

1 x NA: SODIUM ION(Non-functional Binders)

NA.4: 4 residues within 4Å: Chain A: W.72, N.94, E.99, D.116 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:N.94, A:E.99, A:D.116

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Feinberg, H. et al., Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle. J.Biol.Chem. (2013)

Release Date

2013-08-28

Peptides

C-type lectin mincle: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

C-type lectin mincle

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