SMTL ID : 5fs5.1

Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 1.42 Å

Oligo State

monomer

Ligands

1 x KGM: heptyl alpha-D-mannopyranoside(Non-covalent)

KGM.1: 12 residues within 4Å: Chain A: F.1, I.13, N.46, D.47, Y.48, I.52, D.54, Q.133, N.135, N.138, D.140, F.142 10 PLIP interactions: 10 interactions with chain A Hydrophobic interactions: A:Y.48, A:Y.48 Hydrogen bonds: A:F.1, A:N.46, A:D.47, A:Y.48, A:Q.133, A:Q.133, A:N.135, A:D.140

1 x NA: SODIUM ION(Non-functional Binders)

NA.2: 4 residues within 4Å: Chain A: T.5, A.6, N.7, Q.41 6 PLIP interactions: 6 interactions with chain A Hydrogen bonds: A:T.5, A:T.5, A:A.6, A:N.7, A:Q.41 Water bridges: A:N.7

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Rabbani, S. et al., Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ (2017)

Release Date

2016-11-30

Peptides

FIMH: A

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

FIMH

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