SMTL ID : 6gkt.1 (2 other biounits)

X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu

Coordinates

PDB Format

Method

X-RAY DIFFRACTION 2.10 Å

Oligo State

homo-dimer

Ligands

3 x PGE: TRIETHYLENE GLYCOL(Non-functional Binders)

PGE.1: 8 residues within 4Å: Chain A: Y.37, H.55, Q.57, V.65, W.74, R.130 Chain B: E.35, Y.37 3 PLIP interactions: 3 interactions with chain A Hydrogen bonds: A:Q.57 Water bridges: A:Y.37, A:Q.77 PGE.2: 5 residues within 4Å: Chain A: L.5, L.6, P.7, V.8 Chain B: L.6 No protein-ligand interaction detected (PLIP) PGE.4: 10 residues within 4Å: Chain A: E.35, Y.37 Chain B: Y.37, H.55, Q.57, V.65, N.67, W.74, Q.77, R.130 6 PLIP interactions: 1 interactions with chain A, 5 interactions with chain B Hydrogen bonds: A:Y.37, B:Y.37, B:Y.37, B:Q.57, B:N.67, B:Q.77

1 x PG4: TETRAETHYLENE GLYCOL(Non-functional Binders)

PG4.3: 9 residues within 4Å: Chain A: L.29, A.30, N.34 Chain B: P.9, T.11, M.46, E.48, Q.127, W.129 5 PLIP interactions: 4 interactions with chain B, 1 interactions with chain A Hydrogen bonds: B:E.48, B:Q.127, A:N.34 Water bridges: B:Q.127, B:W.129

Links

RCSB   PDBe   PDBj   PDBsum   CATH   PLIP

Citation

Persson, E.K. et al., Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science (2019)

Release Date

2019-06-05

Peptides

Galectin-10: AB

SMTL:PDB

SMTL Chain Id:
PDB Chain Id:

A
A

B
B

Galectin-10

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